PHARMOMICS: A SPECIES- AND TISSUE-SPECIFIC DRUG SIGNATURE DATABASE AND GENE-NETWORK-BASED DRUG REPOSITIONING TOOL

PharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool

Summary: Drug development has been hampered by a high failure rate in clinical trials due to our incomplete understanding of drug functions across organs and species.Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, Wooden Pear and interspecies differences n

read more

A sinister bias for calling fouls in soccer.

Distinguishing between a fair and unfair tackle in soccer can be difficult.For referees, choosing to call a foul often requires a decision despite some level of ambiguity.We were interested in whether a well documented Bodycare set perceptual-motor bias associated with reading direction influenced foul judgments.Prior studies have shown that reader

read more

Ppargamma2 is a key driver of longevity in the mouse.

Aging involves a progressive physiological remodeling that is controlled Gloves by both genetic and environmental factors.Many of these factors impact also on white adipose tissue (WAT), which has been shown to be a determinant of lifespan.Interrogating a transcriptional network for predicted causal regulatory interactions in a collection of mouse

read more